mrna precursor การใช้

• Both the ? and ? subunits are synthesized from a single mRNA precursor.
• Simple illustration of an unspliced mRNA precursor, with two introns and three exons ( top ).
• CPSF-73 is a zinc-dependent hydrolase which cleaves the mRNA precursor just downstream the polyadenylation signal sequence AAUAAA.
• Most eukaryotic mRNA precursors must undergo cleavage and polyadenylation in their 3'- ends before they can function as mRNAs.
• He has also studied the mechanism and regulation of the process by which introns are removed from mRNA precursors, mRNA splicing.
• Heterogeneous nuclear RNAs ( hnRNAs ) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogeneous ribonucleoprotein ( hnRNP ) complexes.
• Eukaryotic mRNA precursors must be processed in the nucleus ( e . g ., capping, polyadenylation, splicing ) before they are exported to the cytoplasm for translation.
• Manley and colleagues identified and characterized the key factors responsible for polyadenylation of mRNA precursors, and elucidated how this remarkably complex machinery functions in gene regulation, for example during cell growth and differentiation.
• CYP4F3 is expressed as two distinct enzymes, CYP4F3A and CYP4F3B, due to alternative splicing of a single pre-mRNA precursor molecule; CYP4F3A is mostly expressed in leukocytes, CYP4F3B mostly in the liver.